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Target
Microtubule-associated protein tau
Ligand
BDBM50313696
Substrate
n/a
Meas. Tech.
ChEMBL_614780 (CHEMBL1113299)
IC50
250±n/a nM
Citation
 Lesuisse, D; Dutruc-Rosset, G; Tiraboschi, G; Dreyer, MK; Maignan, S; Chevalier, A; Halley, F; Bertrand, P; Burgevin, MC; Quarteronet, D; Rooney, T Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2. Bioorg Med Chem Lett 20:1985-9 (2010) [PubMed]  Article 
Target
Name:
Microtubule-associated protein tau
Synonyms:
Mapt | Mtapt | TAU_RAT | Tau
Type:
PROTEIN
Mol. Mass.:
78560.55
Organism:
Rat
Description:
ChEMBL_614780
Residue:
752
Sequence:
MAEPRQEFDTMEDQAGDYTMLQDQEGDMDHGLKESPPQPPADDGSEEPGSETSDAKSTPTAEDVTAPLVEERAPDKQATAQSHTEIPEGTTAEEAGIGDTPNMEDQAAGHVTQEPQKVEIFSQSLLVEPGRREGQAPDSGISDWTHQQVPSMSGAPLPPQGLREATHQPLGTRPEDVERSHPASELLWQESPQKEAWGKDRLGSEEEVDEDITMDESSQESPPSQASLAPGTATPQARSVSASGVSGETTSIPGFPAEGSIPLPADFFSKVSAETQASPPEGPGTGPSEEGHEAAPEFTFHVEIKASAPKEQDLEGATVVGAPAEEQKARGPSVGKGTKEASLLEPTDKQPAAGLPGRPVSRVPQLKARVAGVSKDRTGNDEKKAKTSTPSCAKTPSNRPCLSPTRPTPGSSDPLIKPSSPAVCPEPATSPKYVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAATPGQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVHIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
  
Inhibitor
Name:
BDBM50313696
Synonyms:
CHEMBL1086427 | N-(6-chloro-7-fluoro-5-phenyl-1H-indazol-3-yl)butyramide
Type:
Small organic molecule
Emp. Form.:
C17H15ClFN3O
Mol. Mass.:
331.772
SMILES:
CCCC(=O)Nc1n[nH]c2c(F)c(Cl)c(cc12)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: