Reaction Details
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Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Ligand
BDBM50329874
Substrate
n/a
Meas. Tech.
ChEMBL_675735 (CHEMBL1272369)
IC50
2000±n/a nM
Citation
Potter, A; Oldfield, V; Nunns, C; Fromont, C; Ray, S; Northfield, CJ; Bryant, CJ; Scrace, SF; Robinson, D; Matossova, N; Baker, L; Dokurno, P; Surgenor, AE; Davis, B; Richardson, CM; Murray, JB; Moore, JD Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution. Bioorg Med Chem Lett 20:6483-8 (2010) [PubMed] Article More Info.:
Target
Name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Synonyms:
PIN1 | PIN1_HUMAN | PPIase Pin1 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Type:
PROTEIN
Mol. Mass.:
18248.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1502595
Residue:
163
Sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE
Inhibitor
Name:
BDBM50329874
Synonyms:
4-(benzyl(methyl)carbamoyl)-2-(3-chlorophenyl)-1H-imidazole-5-carboxylic acid | 5-[BENZYL(METHYL)CARBAMOYL]-2-(3-CHLOROPHENYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID | CHEMBL1230288
Type:
Small organic molecule
Emp. Form.:
C19H16ClN3O3
Mol. Mass.:
369.802
SMILES:
CN(Cc1ccccc1)C(=O)c1[nH]c(nc1C(O)=O)-c1cccc(Cl)c1
Structure:
