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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50333727
Substrate
n/a
Meas. Tech.
ChEMBL_700671 (CHEMBL1645710)
Ki
0.330000±n/a nM
Citation
 Li, L; Mathieu, MC; Denis, D; Therien, AG; Wang, Z The identification of substituted benzothiophene derivatives as PGE(2) subtype 4 receptor antagonists: From acid to non-acid. Bioorg Med Chem Lett 21:734-7 (2011) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50333727
Synonyms:
3-(4-((N-(1-(2-methoxyphenyl)cyclopropanecarbonyl)sulfamoyl)methyl)phenyl)-N,N,5,7-tetramethylbenzo[b]thiophene-2-carboxamide | CHEMBL1644006
Type:
Small organic molecule
Emp. Form.:
C31H32N2O5S2
Mol. Mass.:
576.726
SMILES:
COc1ccccc1C1(CC1)C(=O)NS(=O)(=O)Cc1ccc(cc1)-c1c(sc2c(C)cc(C)cc12)C(=O)N(C)C
Structure:
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