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Target
Type-1 angiotensin II receptor
Ligand
BDBM50292633
Substrate
n/a
Meas. Tech.
ChEMBL_717424 (CHEMBL1670323)
IC50
2.9±n/a nM
Citation
 Naik, P; Murumkar, P; Giridhar, R; Yadav, MR Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective. Bioorg Med Chem 18:8418-56 (2010) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_BOVIN | Angiotensin II type 1a (AT-1a) receptor
Type:
PROTEIN
Mol. Mass.:
41107.81
Organism:
Bos taurus
Description:
ChEMBL_36779
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCIEVE
  
Inhibitor
Name:
BDBM50292633
Synonyms:
4'-{[2-n-propyl-4-methyl-6-(1-methylbenzoimidazol-2-yl)benzoimidazol-1-yl]methyl}-2-(1H-imidazoline-2-yl)biphenyl | CHEMBL453934
Type:
Small organic molecule
Emp. Form.:
C35H34N6
Mol. Mass.:
538.6847
SMILES:
CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1C1=NCCN1)-c1nc2ccccc2n1C |t:30|
Structure:
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