Reaction Details Report a problem with these data
Target
B-cell receptor CD22
Ligand
BDBM50338746
Substrate
n/a
Meas. Tech.
ChEMBL_727026 (CHEMBL1686886)
IC50
820±n/a nM
Citation
Abdu-Allah, HH; Watanabe, K; Completo, GC; Sadagopan, M; Hayashizaki, K; Takaku, C; Tamanaka, T; Takematsu, H; Kozutsumi, Y; Paulson, JC; Tsubata, T; Ando, H; Ishida, H; Kiso, M CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold. Bioorg Med Chem 19:1966-71 (2011) [PubMed] Article
More Info.:
Target
Name:
B-cell receptor CD22
Synonyms:
CD22 | CD22_HUMAN | SIGLEC2
Type:
PROTEIN
Mol. Mass.:
95348.60
Organism:
Human
Description:
ChEMBL_727026
Residue:
847
Sequence:
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH
Inhibitor
Name:
BDBM50338746
Synonyms:
Benzyl 3,5,9-trideoxy-5-glycolamido-9-(4'-hydroxy-4-biphenyl)methylamino-D-glycero-alpha-D-galacto-2-nonulopyranosidonic acid | CHEMBL1684363
Type:
Small organic molecule
Emp. Form.:
C31H36N2O10
Mol. Mass.:
596.6249
SMILES:
OCC(=O)N[C@@H]1[C@@H](O)C[C@@](OCc2ccccc2)(O[C@H]1[C@H](O)[C@H](O)CNCc1ccc(cc1)-c1ccc(O)cc1)C(O)=O |r|