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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM50342098
Substrate
n/a
Meas. Tech.
ChEMBL_743931 (CHEMBL1767925)
Ki
57±n/a nM
Citation
 Ezzili, C; Mileni, M; McGlinchey, N; Long, JZ; Kinsey, SG; Hochstatter, DG; Stevens, RC; Lichtman, AH; Cravatt, BF; Bilsky, EJ; Boger, DL Reversible competitivea-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. J Med Chem 54:2805-22 (2011) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM50342098
Synonyms:
CHEMBL1765864 | rac-6-[2-(5-Phenylindane-2-carbonyl)oxazol-5-yl]pyridine-2-carboxylic Acid
Type:
Small organic molecule
Emp. Form.:
C25H18N2O4
Mol. Mass.:
410.4214
SMILES:
OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)C1Cc2ccc(cc2C1)-c1ccccc1
Structure:
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