Reaction Details Report a problem with these data
Target
B1 bradykinin receptor
Ligand
BDBM50344099
Substrate
n/a
Meas. Tech.
ChEMBL_748611 (CHEMBL1780464)
Ki
0.1±n/a nM
Citation
Chen, JJ; Nguyen, T; D'Amico, DC; Qian, W; Human, J; Aya, T; Biswas, K; Fotsch, C; Han, N; Liu, Q; Nishimura, N; Peterkin, TA; Yang, K; Zhu, J; Riahi, BB; Hungate, RW; Andersen, NG; Colyer, JT; Faul, MM; Kamassah, A; Wang, J; Jona, J; Kumar, G; Johnson, E; Askew, BC 3-Oxo-2-piperazinyl acetamides as potent bradykinin B1 receptor antagonists for the treatment of pain and inflammation. Bioorg Med Chem Lett 21:3384-9 (2011) [PubMed] Article
More Info.:
Target
Name:
B1 bradykinin receptor
Synonyms:
B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor
Type:
Enzyme
Mol. Mass.:
40508.87
Organism:
Human
Description:
P46663
Residue:
353
Sequence:
MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLLVFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKANLFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRCGGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFFAFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
Inhibitor
Name:
BDBM50344099
Synonyms:
2-(1-(5-chlorobenzo[b]thiophen-2-ylsulfonyl)-3-oxopiperazin-2-yl)-N-((R)-6-(piperidin-1-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-yl)acetamide | CHEMBL1777957
Type:
Small organic molecule
Emp. Form.:
C30H35ClN4O4S2
Mol. Mass.:
615.206
SMILES:
Clc1ccc2sc(cc2c1)S(=O)(=O)N1CCNC(=O)C1CC(=O)N[C@@H]1CCCc2cc(CN3CCCCC3)ccc12 |r|