Reaction Details Report a problem with these data
Target
Oxa40
Ligand
BDBM50347180
Substrate
n/a
Meas. Tech.
ChEMBL_754356 (CHEMBL1799222)
IC50
>50000±n/a nM
Citation
 Tan, Q; Ogawa, AM; Raghoobar, SL; Wisniewski, D; Colwell, L; Park, YW; Young, K; Hermes, JD; Dininno, FP; Hammond, ML Thiophenyl oxime-derived phosphonates as nano-molar class C beta-lactamase inhibitors reducing MIC of imipenem against Pseudomonas aeruginosa and Acinetobacter baumannii. Bioorg Med Chem Lett 21:4363-5 (2011) [PubMed]  Article 
Target
Name:
Oxa40
Synonyms:
Beta-lactamase | Class D β-lactamase (OXA-24)
Type:
Enzyme
Mol. Mass.:
30946.50
Organism:
Acinetobacter baumannii
Description:
Q8RLA6
Residue:
275
Sequence:
MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII
  
Inhibitor
Name:
BDBM50347180
Synonyms:
CHEMBL1795563
Type:
Small organic molecule
Emp. Form.:
C14H13FN5O5PS
Mol. Mass.:
413.321
SMILES:
CO\N=C(/C(=O)NCP(O)(=O)Oc1ccc(C#N)c(F)c1)c1cnc(N)s1
Structure:
Search PDB for entries with ligand similarity: