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Target
Beta-lactamase
Ligand
BDBM50348178
Substrate
n/a
Meas. Tech.
ChEMBL_757191 (CHEMBL1803415)
IC50
1500±n/a nM
Citation
 Chen, H; Blizzard, TA; Kim, S; Wu, J; Young, K; Park, YW; Ogawa, AM; Raghoobar, S; Painter, RE; Wisniewski, D; Hairston, N; Fitzgerald, P; Sharma, N; Scapin, G; Lu, J; Hermes, J; Hammond, ML Side chain SAR of bicyclicß-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712. Bioorg Med Chem Lett 21:4267-70 (2011) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_PSEAE | ampC | beta-Lactamase
Type:
Enzyme
Mol. Mass.:
43406.87
Organism:
Pseudomonas aeruginosa (PAO1)
Description:
P24735
Residue:
397
Sequence:
MRDTRFPCLCGIAASTLLFATTPAIAGEAPADRLKALVDAAVQPVMKANDIPGLAVAISLKGEPHYFSYGLASKEDGRRVTPETLFEIGSVSKTFTATLAGYALTQDKMRLDDRASQHWPALQGSRFDGISLLDLATYTAGGLPLQFPDSVQKDQAQIRDYYRQWQPTYAPGSQRLYSNPSIGLFGYLAARSLGQPFERLMEQQVFPALGLEQTHLDVPEAALAQYAQGYGKDDRPLRVGPGPLDAEGYGVKTSAADLLRFVDANLHPERLDRPWAQALDATHRGYYKVGDMTQGLGWEAYDWPISLKRLQAGNSTPMALQPHRIARLPAPQALEGQRLLNKTGSTNGFGAYVAFVPGRDLGLVILANRNYPNAERVKIAYAILSGLEQQGKVPLKR
  
Inhibitor
Name:
BDBM50348178
Synonyms:
CHEMBL1800867
Type:
Small organic molecule
Emp. Form.:
C14H24N4O5S
Mol. Mass.:
360.429
SMILES:
C[N+]1(C)CCC[C@@H](CC1)NC(=O)N1CC[C@@H]2[C@H]1C(=O)N2S([O-])(=O)=O |r|
Structure:
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