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Target
Cyclin-dependent kinase 2
Ligand
BDBM50348249
Substrate
n/a
Meas. Tech.
ChEMBL_757436 (CHEMBL1804256)
IC50
940±n/a nM
Citation
 Lee, J; Kim, KH; Jeong, S Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors. Bioorg Med Chem Lett 21:4203-5 (2011) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50348249
Synonyms:
CHEMBL1800461
Type:
Small organic molecule
Emp. Form.:
C18H23N5O4
Mol. Mass.:
373.4063
SMILES:
Nc1nc(cc(n1)-c1cc(ccc1O)N1C[C@H](O)[C@@H](O)C1)N1CCOCC1 |r|
Structure:
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