Reaction Details Report a problem with these data
Target
Cannabinoid receptor 2
Ligand
BDBM50341023
Substrate
n/a
Meas. Tech.
ChEMBL_757478 (CHEMBL1804450)
EC50
67±n/a nM
Citation
 Zindell, R; Walker, ER; Scott, J; Amouzegh, P; Wu, L; Ermann, M; Thomson, D; Fisher, MB; Fullenwider, CL; Grbic, H; Kaplita, P; Linehan, B; Patel, M; Patel, M; Löbbe, S; Block, S; Albrecht, C; Gemkow, MJ; Shih, DT; Riether, D Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: optimization of drug-like properties and target independent parameters. Bioorg Med Chem Lett 21:4276-80 (2011) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 2
Synonyms:
CANNABINOID CB2 | CB-2 | CB2 | CB2A | CB2B | CNR2 | CNR2_HUMAN | CX5 | Cannabinoid CB2 receptor | Cannabinoid receptor 2 (CB2) | Cannabinoid receptor 2 (CB2R) | hCB2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
39690.94
Organism:
Homo sapiens (Human)
Description:
P34972
Residue:
360
Sequence:
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
  
Inhibitor
Name:
BDBM50341023
Synonyms:
CHEMBL1762293 | N-(5-tert-butylisoxazol-3-yl)-4-(tetrahydro-2H-pyran-4-carbonyl)-1,4-diazepane-1-carboxamide
Type:
Small organic molecule
Emp. Form.:
C19H30N4O4
Mol. Mass.:
378.4659
SMILES:
CC(C)(C)c1cc(NC(=O)N2CCCN(CC2)C(=O)C2CCOCC2)no1
Structure:
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