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Target
Pyruvate kinase PKM
Ligand
BDBM50361556
Substrate
n/a
Meas. Tech.
ChEMBL_797232 (CHEMBL1942547)
EC50
73±n/a nM
Citation
 Walsh, MJ; Brimacombe, KR; Veith, H; Bougie, JM; Daniel, T; Leister, W; Cantley, LC; Israelsen, WJ; Vander Heiden, MG; Shen, M; Auld, DS; Thomas, CJ; Boxer, MB 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorg Med Chem Lett 21:6322-7 (2011) [PubMed]  Article 
Target
Name:
Pyruvate kinase PKM
Synonyms:
KPYM_HUMAN | OIP3 | PK2 | PK3 | PKM | PKM2 | Pyruvate kinase (PKM2)
Type:
Protein
Mol. Mass.:
57944.31
Organism:
Human
Description:
P14618
Residue:
531
Sequence:
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
  
Inhibitor
Name:
BDBM50361556
Synonyms:
CHEMBL1085587
Type:
Small organic molecule
Emp. Form.:
C18H17N3O3S2
Mol. Mass.:
387.476
SMILES:
COc1cccc(Cn2ncc3c4sc(cc4n(C)c3c2=O)S(C)=O)c1
Structure:
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