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Target
Low molecular weight protein-tyrosine phosphatase A
Ligand
BDBM50363165
Substrate
n/a
Meas. Tech.
ChEMBL_801141 (CHEMBL1948968)
IC50
8800±n/a nM
Citation
 Chiaradia, LD; Martins, PG; Cordeiro, MN; Guido, RV; Ecco, G; Andricopulo, AD; Yunes, RA; Vernal, J; Nunes, RJ; Terenzi, H Synthesis, biological evaluation, and molecular modeling of chalcone derivatives as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatases (PtpA and PtpB). J Med Chem 55:390-402 (2012) [PubMed]  Article 
Target
Name:
Low molecular weight protein-tyrosine phosphatase A
Synonyms:
PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA
Type:
Hydrolase
Mol. Mass.:
17891.84
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
163
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
  
Inhibitor
Name:
BDBM50363165
Synonyms:
PRODIGIOSIN
Type:
Small organic molecule
Emp. Form.:
C20H25N3O
Mol. Mass.:
323.432
SMILES:
CCCCCc1cc(=Cc2[nH]c(cc2OC)-c2ccc[nH]2)[nH]c1=C |w:8.8|
Structure:
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