Reaction Details Report a problem with these data
Target
Serine protease 1
Ligand
BDBM50291170
Substrate
n/a
Meas. Tech.
ChEBML_212354
IC50
230±n/a nM
Citation
 Akiyama, Y; Tsutsumi, S; Hatsushiba, E; Ohuchi, S; Okonogi, T Peptidyl -keto thiazole as potent thrombin inhibitors Bioorg Med Chem Lett 7:533-538 (1997)    Article 
Target
Name:
Serine protease 1
Synonyms:
Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I
Type:
Enzyme
Mol. Mass.:
25790.52
Organism:
Bovine
Description:
P00760
Residue:
246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN
  
Inhibitor
Name:
BDBM50291170
Synonyms:
(S)-1-((R)-2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [(R)-4-guanidino-1-(thiazole-2-carbonyl)-butyl]-amide | CHEMBL149527
Type:
Small organic molecule
Emp. Form.:
C25H33N7O4S
Mol. Mass.:
527.639
SMILES:
CC(=O)N[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(=O)c1nccs1
Structure:
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