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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM50038416
Substrate
n/a
Meas. Tech.
ChEBML_144178
Ki
>100000±n/a nM
Citation
 Ayers, JT; Dwoskin, LP; Deaciuc, AG; Grinevich, VP; Zhu, J; Crooks, PA bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors. Bioorg Med Chem Lett 12:3067-71 (2002) [PubMed]  Article 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR)
Type:
Enzyme
Mol. Mass.:
56502.44
Organism:
Rattus norvegicus (Rat)
Description:
Q05941
Residue:
502
Sequence:
MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHLMHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM50038416
Synonyms:
(1,6-trimethyl ammonium)hexane; dibromide | CHEMBL100622 | CHEMBL332524 | HEXAMETHONIUM | HEXAMETHONIUM BROMIDE | HEXAMETHONIUM CHLORIDE | Hexamethoniumdibromide | N,N,N,N'',N'',N''-Hexamethyl-1,6-hexanediaminium dibromide | N,N,N,N'',N'',N''-Hexamethylhexane-1,6-diammoniumdibromide
Type:
Small organic molecule
Emp. Form.:
C12H30N2
Mol. Mass.:
202.3789
SMILES:
C[N+](C)(C)CCCCCC[N+](C)(C)C
Structure:
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