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Target
Cytosol aminopeptidase
Ligand
BDBM50027045
Substrate
n/a
Meas. Tech.
ChEMBL_98522 (CHEMBL706542)
Ki
20000±n/a nM
Citation
 Rich, DH; Moon, BJ; Harbeson, S Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes. J Med Chem 27:417-22 (1984) [PubMed]  Article 
Target
Name:
Cytosol aminopeptidase
Synonyms:
AMPL_HUMAN | Aminopeptidase | LAP3 | LAPEP | Leucine aminopeptidase | PEPS
Type:
PROTEIN
Mol. Mass.:
56171.75
Organism:
Human
Description:
ChEMBL_1507539
Residue:
519
Sequence:
MFLLPLPAAGRVVVRRLAVRRFGSRSLSTADMTKGLVLGIYSKEKEDDVPQFTSAGENFDKLLAGKLRETLNISGPPLKAGKTRTFYGLHQDFPSVVLVGLGKKAAGIDEQENWHEGKENIRAAVAAGCRQIQDLELSSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKMAVSAKLYGSGDQEAWQKGVLFASGQNLARQLMETPANEMTPTRFAEIIEKNLKSASSKTEVHIRPKSWIEEQAMGSFLSVAKGSDEPPVFLEIHYKGSPNANEPPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRAKNGKTIQVDNTDAEGRLILADALCYAHTFNPKVILNAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVVDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMTGRPTRTLIEFLLRFSQDNA
  
Inhibitor
Name:
BDBM50027045
Synonyms:
2-{2-[2-(3-Amino-2-hydroxy-5-methyl-hexanoylamino)-3-methyl-butyrylamino]-3-methyl-butyrylamino}-succinic acid | CHEMBL2370764
Type:
Small organic molecule
Emp. Form.:
C21H38N4O8
Mol. Mass.:
474.5484
SMILES:
CC(C)C[C@H](N)[C@@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
Structure:
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