Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50055413
Substrate
n/a
Meas. Tech.
ChEMBL_156362 (CHEMBL761692)
IC50
12000±n/a nM
Citation
 Teshirogi, I; Matsutani, S; Shirahase, K; Fujii, Y; Yoshida, T; Tanaka, K; Ohtani, M Synthesis and phospholipase A2 inhibitory activity of thielocin B3 derivatives. J Med Chem 39:5183-91 (1997) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
PA2GA_RAT | Phospholipase A2 group IIA | Pla2g2a
Type:
PROTEIN
Mol. Mass.:
16307.95
Organism:
Rattus norvegicus
Description:
ChEMBL_537135
Residue:
146
Sequence:
MKVLLLLAVVIMAFGSIQVQGSLLEFGQMILFKTGKRADVSYGFYGCHCGVGGRGSPKDATDWCCVTHDCCYNRLEKRGCGTKFLTYKFSYRGGQISCSTNQDSCRKQLCQCDKAAAECFARNKKSYSLKYQFYPNKFCKGKTPSC
  
Inhibitor
Name:
BDBM50055413
Synonyms:
CHEMBL384002 | Thielocin B3
Type:
Small organic molecule
Emp. Form.:
C62H66O20
Mol. Mass.:
1131.1754
SMILES:
COc1c(C)c(OC(=O)c2c(C)c(C)c(OC(=O)c3c(C)cc(O)c(Cc4c(C)c(C(=O)Oc5c(C)c(C)c(C(=O)Oc6c(C)c(C)c(C(O)=O)c(OC)c6C)c(OC)c5C)c(O)c(C)c4O)c3O)c(C)c2OC)c(C)c(C)c1C(O)=O
Structure:
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