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Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50074372
Substrate
n/a
Meas. Tech.
ChEMBL_51131 (CHEMBL664192)
Ki
22±n/a nM
Citation
 Hodge, CN; Aldrich, PE; Wasserman, ZR; Fernandez, CH; Nemeth, GA; Arvanitis, A; Cheeseman, RS; Chorvat, RJ; Ciganek, E; Christos, TE; Gilligan, PJ; Krenitsky, P; Scholfield, E; Strucely, P Corticotropin-releasing hormone receptor antagonists: framework design and synthesis guided by ligand conformational studies. J Med Chem 42:819-32 (1999) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
47870.75
Organism:
Rattus norvegicus (rat)
Description:
Receptor binding assays were performed using rat cortex homogenate.
Residue:
415
Sequence:
MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50074372
Synonyms:
(2-Bromo-4-isopropyl-phenyl)-ethyl-(4-methyl-6-morpholin-4-yl-pyrimidin-2-yl)-amine | CHEMBL432496
Type:
Small organic molecule
Emp. Form.:
C20H27BrN4O
Mol. Mass.:
419.359
SMILES:
CCN(c1nc(C)cc(n1)N1CCOCC1)c1ccc(cc1Br)C(C)C
Structure:
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