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Target
Prothrombin
Ligand
BDBM50113931
Substrate
n/a
Meas. Tech.
ChEMBL_48316 (CHEMBL658079)
Ki
>5000±n/a nM
Citation
 Phillips, G; Guilford, WJ; Buckman, BO; Davey, DD; Eagen, KA; Koovakkat, S; Liang, A; McCarrick, M; Mohan, R; Ng, HP; Pinkerton, M; Subramanyam, B; Ho, E; Trinh, L; Whitlow, M; Wu, S; Xu, W; Morrissey, MM Design, synthesis, and activity of a novel series of factor Xa inhibitors: optimization of arylamidine groups. J Med Chem 45:2484-93 (2002) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50113931
Synonyms:
3-[6-(3-Chloro-phenoxy)-3,5-difluoro-4-methyl-pyridin-2-yloxy]-benzamidine | CHEMBL84030
Type:
Small organic molecule
Emp. Form.:
C19H14ClF2N3O2
Mol. Mass.:
389.783
SMILES:
Cc1c(F)c(Oc2cccc(Cl)c2)nc(Oc2cccc(c2)C(N)=N)c1F
Structure:
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