Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM107693
Substrate
n/a
Meas. Tech.
ChEMBL_88611 (CHEMBL701715)
IC50
520±n/a nM
Citation
 Pais, GC; Zhang, X; Marchand, C; Neamati, N; Cowansage, K; Svarovskaia, ES; Pathak, VK; Tang, Y; Nicklaus, M; Pommier, Y; Burke, TR Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors. J Med Chem 45:3184-94 (2002) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM107693
Synonyms:
(2Z)-4-(5-chloro-1H-indol-3-yl)-2-hydroxy-4-oxobut-2- enoic acid (Compound 19) | CHEMBL108760
Type:
Small organic molecule
Emp. Form.:
C12H8ClNO4
Mol. Mass.:
265.649
SMILES:
OC(=O)C(=O)CC(=O)c1c[nH]c2ccc(Cl)cc12
Structure:
Search PDB for entries with ligand similarity: