Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM10866
Substrate
n/a
Meas. Tech.
ChEMBL_302691 (CHEMBL838574)
Ki
240±n/a nM
Citation
 Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett 15:1149-54 (2005) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
  
Inhibitor
Name:
BDBM10866
Synonyms:
4-amino-6-(trifluoromethyl)benzene-1,3-disulfonamide | CHEMBL418 | aromatic/heteroaromatic sulfonamide 11
Type:
Small organic molecule
Emp. Form.:
C7H8F3N3O4S2
Mol. Mass.:
319.281
SMILES:
Nc1cc(c(cc1S(N)(=O)=O)S(N)(=O)=O)C(F)(F)F
Structure:
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