Reaction Details Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM50163631
Substrate
n/a
Meas. Tech.
ChEMBL_302883 (CHEMBL828797)
Ki
12±n/a nM
Citation
 Janssens, F; Leenaerts, J; Diels, G; De Boeck, B; Megens, A; Langlois, X; van Rossem, K; Beetens, J; Borgers, M Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines. J Med Chem 48:2154-66 (2005) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50163631
Synonyms:
1-Methyl-4-piperidin-4-ylidene-1,4-dihydro-1,5,7a-triaza-cyclopenta[f]azulen-9-one; oxalic acid | CHEMBL444353
Type:
Small organic molecule
Emp. Form.:
C16H18N4O
Mol. Mass.:
282.3403
SMILES:
[#6]-n1ccc2c1-[#6](=O)-[#6]-n1ccnc1\[#6]-2=[#6]-1/[#6]-[#6]-[#7]-[#6]-[#6]-1
Structure:
Search PDB for entries with ligand similarity: