Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM50169769
Substrate
n/a
Meas. Tech.
ChEMBL_469263 (CHEMBL949945)
IC50
3100±n/a nM
Citation
 Maryanoff, BE; Costanzo, MJ Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem 16:1562-95 (2008) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50169769
Synonyms:
(S)-1-cyclohexylpropan-2-yl (S)-1-oxo-1-(thiazol-2-yl)hexan-2-ylcarbamate | CHEMBL361975 | [(S)-1-(Thiazole-2-carbonyl)-pentyl]-carbamic acid (S)-2-cyclohexyl-1-methyl-ethyl ester
Type:
Small organic molecule
Emp. Form.:
C19H30N2O3S
Mol. Mass.:
366.518
SMILES:
CCCC[C@H](NC(=O)O[C@@H](C)CC1CCCCC1)C(=O)c1nccs1
Structure:
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