Reaction Details Report a problem with these data
Target
Eukaryotic translation initiation factor 4E
Ligand
BDBM50316302
Substrate
n/a
Meas. Tech.
ChEMBL_826735 (CHEMBL2051182)
Ki
28±n/a nM
Citation
Chen, X; Kopecky, DJ; Mihalic, J; Jeffries, S; Min, X; Heath, J; Deignan, J; Lai, S; Fu, Z; Guimaraes, C; Shen, S; Li, S; Johnstone, S; Thibault, S; Xu, H; Cardozo, M; Shen, W; Walker, N; Kayser, F; Wang, Z Structure-guided design, synthesis, and evaluation of guanine-derived inhibitors of the eIF4E mRNA-cap interaction. J Med Chem 55:3837-51 (2012) [PubMed] Article
More Info.:
Target
Name:
Eukaryotic translation initiation factor 4E
Synonyms:
EIF4E | EIF4EL1 | EIF4F | Eukaryotic translation initation factor | Eukaryotic translation initiation factor 4E (eIF4E) | Eukaryotic translation initiation factor 4E/Eukaryotic translation initiation factor 4E-binding protein 1 | IF4E_HUMAN
Type:
Protein
Mol. Mass.:
25095.44
Organism:
Human
Description:
P06730
Residue:
217
Sequence:
MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
Inhibitor
Name:
BDBM50316302
Synonyms:
((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate | CHEMBL1094973
Type:
Small organic molecule
Emp. Form.:
C11H18N5O14P3
Mol. Mass.:
537.207
SMILES:
C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r|