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Target
Histone deacetylase 3
Ligand
BDBM50392111
Substrate
n/a
Meas. Tech.
ChEMBL_851449 (CHEMBL2156455)
IC50
>30000±n/a nM
Citation
 Suzuki, T; Khan, MN; Sawada, H; Imai, E; Itoh, Y; Yamatsuta, K; Tokuda, N; Takeuchi, J; Seko, T; Nakagawa, H; Miyata, N Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. J Med Chem 55:5760-73 (2012) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50392111
Synonyms:
CHEMBL2152613
Type:
Small organic molecule
Emp. Form.:
C21H20N2O2
Mol. Mass.:
332.3957
SMILES:
NC(=O)c1ccccc1Nc1cccc(OCCc2ccccc2)c1
Structure:
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