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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50393574
Substrate
n/a
Meas. Tech.
ChEMBL_855309 (CHEMBL2161793)
EC50
118.1±n/a nM
Citation
 Liu, Q; Li, N; Yuan, Y; Lu, H; Wu, X; Zhou, C; He, M; Su, H; Zhang, M; Wang, J; Wang, B; Wang, Y; Ma, D; Ye, Y; Weiss, HC; Gesing, ER; Liao, J; Wang, MW Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor. J Med Chem 55:250-67 (2012) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP1R_RAT | Glp1r | Glpr
Type:
PROTEIN
Mol. Mass.:
52889.73
Organism:
Rattus norvegicus
Description:
ChEMBL_855307
Residue:
463
Sequence:
MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
  
Inhibitor
Name:
BDBM50393574
Synonyms:
CHEMBL2158422
Type:
Small organic molecule
Emp. Form.:
C48H40N4O14S2
Mol. Mass.:
960.98
SMILES:
COc1cc(ccc1OC(=O)c1cccs1)[C@H]1[C@@](NC(=O)c2ccc(NC(C)=O)cc2)([C@@H](c2ccc(OC(=O)c3cccs3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(C)=O)cc1)C(O)=O)C(O)=O |r,wU:16.17,48.54,31.34,17.19,wD:48.68,17.71,(32.36,-35.86,;31.04,-36.65,;29.69,-35.9,;28.37,-36.69,;27.03,-35.94,;27,-34.41,;28.31,-33.61,;29.67,-34.36,;30.98,-33.57,;30.96,-32.03,;29.61,-31.28,;32.2,-31.12,;33.67,-31.6,;34.58,-30.35,;33.67,-29.11,;32.21,-29.58,;25.71,-36.73,;25.71,-38.28,;26.78,-39.39,;26.77,-40.93,;25.43,-41.69,;28.1,-41.71,;28.08,-43.25,;29.4,-44.03,;30.75,-43.27,;32.07,-44.05,;32.06,-45.59,;30.72,-46.35,;33.39,-46.36,;30.75,-41.72,;29.43,-40.94,;24.17,-38.27,;23.38,-39.57,;24.1,-40.92,;23.31,-42.24,;21.77,-42.21,;20.97,-43.52,;21.71,-44.88,;23.24,-44.91,;20.76,-46.09,;19.21,-46.05,;18.69,-47.5,;19.91,-48.44,;21.18,-47.58,;21.03,-40.85,;19.49,-40.82,;18.75,-39.46,;21.83,-39.54,;24.17,-36.74,;23.4,-35.4,;24.17,-34.07,;25.71,-34.07,;23.4,-32.74,;24.17,-31.41,;23.4,-30.08,;21.86,-30.08,;21.09,-28.74,;21.86,-27.41,;23.4,-27.41,;21.08,-26.08,;21.09,-31.42,;21.87,-32.75,;22.63,-36.74,;21.86,-35.4,;21.86,-38.07,;27.25,-38.27,;28.02,-39.61,;27.77,-37.21,)|
Structure:
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