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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50393583
Substrate
n/a
Meas. Tech.
ChEMBL_855309 (CHEMBL2161793)
EC50
19055±n/a nM
Citation
 Liu, Q; Li, N; Yuan, Y; Lu, H; Wu, X; Zhou, C; He, M; Su, H; Zhang, M; Wang, J; Wang, B; Wang, Y; Ma, D; Ye, Y; Weiss, HC; Gesing, ER; Liao, J; Wang, MW Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor. J Med Chem 55:250-67 (2012) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP1R_RAT | Glp1r | Glpr
Type:
PROTEIN
Mol. Mass.:
52889.73
Organism:
Rat
Description:
ChEMBL_855307
Residue:
463
Sequence:
MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
  
Inhibitor
Name:
BDBM50393583
Synonyms:
CHEMBL2158313
Type:
Small organic molecule
Emp. Form.:
C56H56N4O16S2
Mol. Mass.:
1105.191
SMILES:
COc1cc(ccc1OC(=O)c1ccc(C)s1)[C@H]1[C@@](NC(=O)c2ccc(NC(=O)OC(C)(C)C)cc2)([C@@H](c2ccc(OC(=O)c3ccc(C)s3)c(OC)c2)[C@]1(NC(=O)c1ccc(NC(=O)OC(C)(C)C)cc1)C(O)=O)C(O)=O |r,wU:36.39,18.20,17.18,54.60,wD:18.81,54.78,(-.94,-8.57,;-.2,-9.92,;1.34,-9.96,;2.14,-8.65,;3.69,-8.68,;4.41,-10.03,;3.62,-11.35,;2.07,-11.32,;1.27,-12.63,;-.27,-12.59,;-1.01,-11.24,;-1.15,-13.86,;-.64,-15.32,;-1.87,-16.25,;-3.13,-15.37,;-4.59,-15.87,;-2.68,-13.9,;4.48,-7.38,;4.48,-5.84,;3.71,-4.51,;4.48,-3.18,;6.02,-3.17,;3.71,-1.84,;4.48,-.51,;3.71,.82,;2.17,.82,;1.4,2.15,;2.16,3.49,;1.39,4.82,;3.7,3.49,;4.47,4.82,;6.01,4.83,;3.7,6.16,;5.23,6.17,;1.4,-.53,;2.17,-1.85,;6.02,-5.84,;7.34,-5.05,;8.68,-5.8,;10,-5.01,;9.97,-3.47,;11.29,-2.67,;12.64,-3.42,;13.96,-2.62,;12.67,-4.96,;11.44,-5.89,;11.94,-7.35,;13.48,-7.32,;14.41,-8.55,;13.93,-5.85,;8.62,-2.72,;8.58,-1.18,;9.9,-.38,;7.3,-3.52,;6.02,-7.38,;7.09,-8.5,;7.08,-10.04,;5.74,-10.79,;8.4,-10.82,;8.38,-12.35,;9.71,-13.13,;11.05,-12.37,;12.38,-13.15,;12.37,-14.69,;13.7,-15.47,;11.03,-15.45,;11.02,-16.99,;9.68,-17.75,;12.35,-17.77,;11.03,-18.54,;11.06,-10.82,;9.73,-10.05,;7.55,-7.38,;8.32,-8.71,;8.07,-6.32,;2.93,-5.84,;2.16,-4.51,;2.16,-7.18,)|
Structure:
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