Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50394694
Substrate
n/a
Meas. Tech.
ChEMBL_858637 (CHEMBL2166519)
EC50
6.17±n/a nM
Citation
 Birnkammer, T; Spickenreither, A; Brunskole, I; Lopuch, M; Kagermeier, N; Bernhardt, G; Dove, S; Seifert, R; Elz, S; Buschauer, A The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists. J Med Chem 55:1147-60 (2012) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Human
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50394694
Synonyms:
CHEMBL2165642
Type:
Small organic molecule
Emp. Form.:
C24H40N10O2
Mol. Mass.:
500.6402
SMILES:
NC(NC(=O)CCCCCCCCC(=O)NC(=N)NCCCc1cnc[nH]1)=NCCCc1cnc[nH]1 |w:27.28|
Structure:
Search PDB for entries with ligand similarity: