Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50350223
Substrate
n/a
Meas. Tech.
ChEMBL_861913 (CHEMBL2173641)
IC50
>300000±n/a nM
Citation
 Abdel Aziz, MH; Sidhu, PS; Liang, A; Kim, JY; Mosier, PD; Zhou, Q; Farrell, DH; Desai, UR Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition. J Med Chem 55:6888-97 (2012) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Human
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50350223
Synonyms:
CHEMBL1812010
Type:
Small organic molecule
Emp. Form.:
C26H25O13S
Mol. Mass.:
577.534
SMILES:
CCOC(=O)c1c(C)oc2cc(OC)c(OCc3oc4cc(OC)c(OS([O-])(=O)=O)cc4c3C(=O)OCC)cc12
Structure:
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