Reaction Details Report a problem with these data
Target
fMet-Leu-Phe receptor
Ligand
BDBM50419379
Substrate
n/a
Meas. Tech.
ChEMBL_788190 (CHEMBL1919337)
IC50
158±n/a nM
Citation
 Morley, AD; Cook, A; King, S; Roberts, B; Lever, S; Weaver, R; Macdonald, C; Unitt, J; Fagura, M; Phillips, T; Lewis, R; Wenlock, M Discovery of pyrazoles as novel FPR1 antagonists. Bioorg Med Chem Lett 21:6456-60 (2011) [PubMed]  Article 
Target
Name:
fMet-Leu-Phe receptor
Synonyms:
FPR | FPR1 | FPR1_HUMAN | Formyl peptide Receptor | N-formyl peptide receptor 1 | N-formylpeptide chemoattractant receptor | fMLP receptor | fMet-Leu-Phe receptor | formyl peptide receptor 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38456.14
Organism:
Human
Description:
gi_4503779
Residue:
350
Sequence:
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
  
Inhibitor
Name:
BDBM50419379
Synonyms:
CHEMBL1916280
Type:
Small organic molecule
Emp. Form.:
C22H26N4O3S
Mol. Mass.:
426.532
SMILES:
CCC(C)NC(=O)c1c(C)nn(c1NS(=O)(=O)c1ccc(C)cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: