Reaction Details Report a problem with these data
Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50423976
Substrate
n/a
Meas. Tech.
ChEMBL_935595 (CHEMBL2320377)
EC50
260±n/a nM
Citation
 Futatsugi, K; Mascitti, V; Guimarães, CR; Morishita, N; Cai, C; DeNinno, MP; Gao, H; Hamilton, MD; Hank, R; Harris, AR; Kung, DW; Lavergne, SY; Lefker, BA; Lopaze, MG; McClure, KF; Munchhof, MJ; Preville, C; Robinson, RP; Wright, SW; Bonin, PD; Cornelius, P; Chen, Y; Kalgutkar, AS From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor. Bioorg Med Chem Lett 23:194-7 (2012) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50423976
Synonyms:
CHEMBL2313410
Type:
Small organic molecule
Emp. Form.:
C21H27FN4O4S
Mol. Mass.:
450.527
SMILES:
CC(C)OC(=O)N1CCC(CC1)n1cc2CN(Cc2n1)c1ccc(cc1F)S(C)(=O)=O
Structure:
Search PDB for entries with ligand similarity: