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Target
NAD-dependent protein deacetylase
Ligand
BDBM50378583
Substrate
n/a
Meas. Tech.
ChEMBL_936768 (CHEMBL2320160)
IC50
35200±n/a nM
Citation
 Zheng, W Sirtuins as emerging anti-parasitic targets. Eur J Med Chem 59:132-40 (2013) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase
Synonyms:
Putative silent information regulator 2 | SIR2-like protein | SIR2RP1
Type:
PROTEIN
Mol. Mass.:
40532.98
Organism:
Leishmania infantum
Description:
ChEMBL_936768
Residue:
373
Sequence:
MTASPRAPHQEHVLGEPTLEGLAHYIREKNVRRILVLVGAGASVAAGIPDFRSPDTGIYANLGKYNLEDPTDAFSLTLLREKPEIFYSIARELNLWPGHFQPTAVHHFIRLLQDEGRLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECHTPFSIEQNYLEAMSGTVSRCSTCGGIVKPNVVFFGENLPDAFFDALHHDAPIAELVIIIGTSMQVHPFALLPCVVPKSVPRVVMNRERVGGLLFRFPDDPLNTVHEDAVAKEGRSSSSQSRSPSASPRREEGGTEDSPSSPNEEVEEASTSSSSDGYGQYGDYHAHPDVCRDVLFRGDCQENVVTLAEYLGLSEALAKRMRLSDAAPATAQRAPNET
  
Inhibitor
Name:
BDBM50378583
Synonyms:
SURFACTIN
Type:
Small organic molecule
Emp. Form.:
C53H93N7O13
Mol. Mass.:
1036.3446
SMILES:
CC(C)CCCCCCCCC[C@@H]1CC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O1 |r|
Structure:
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