Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM50424728
Substrate
n/a
Meas. Tech.
ChEMBL_934323 (CHEMBL2320309)
Ki
>15000±n/a nM
Citation
 Friberg, A; Vigil, D; Zhao, B; Daniels, RN; Burke, JP; Garcia-Barrantes, PM; Camper, D; Chauder, BA; Lee, T; Olejniczak, ET; Fesik, SW Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J Med Chem 56:15-30 (2013) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50424728
Synonyms:
CHEMBL2314172
Type:
Small organic molecule
Emp. Form.:
C29H25NO3
Mol. Mass.:
435.5137
SMILES:
OC(=O)c1c(CCCOc2cccc3ccccc23)c2ccccc2n1Cc1ccccc1
Structure:
Search PDB for entries with ligand similarity: