Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-5
Ligand
BDBM50434767
Substrate
n/a
Meas. Tech.
ChEMBL_962205 (CHEMBL2388793)
Ki
800±n/a nM
Citation
 Micale, N; Ettari, R; Lavecchia, A; Di Giovanni, C; Scarbaci, K; Troiano, V; Grasso, S; Novellino, E; Schirmeister, T; Zappalà, M Development of peptidomimetic boronates as proteasome inhibitors. Eur J Med Chem 64:23-34 (2013) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50434767
Synonyms:
CHEMBL2385811
Type:
Small organic molecule
Emp. Form.:
C16H28BN3O4
Mol. Mass.:
337.222
SMILES:
CCN(CC)c1ccn(CC(=O)N[C@@H](CC(C)C)B(O)O)c(=O)c1 |r|
Structure:
Search PDB for entries with ligand similarity: