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Target
Major prion protein
Ligand
BDBM80521
Substrate
n/a
Meas. Tech.
ChEMBL_972294 (CHEMBL2411805)
EC50
212±n/a nM
Citation
 Li, Z; Rao, S; Gever, JR; Widjaja, K; Prusiner, SB; Silber, BM Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds. ACS Med Chem Lett 4:647-650 (2013) [PubMed]  Article 
Target
Name:
Major prion protein
Synonyms:
CD_antigen=CD230 | PRIO_SHEEP | PRNP | PRP | SIP
Type:
PROTEIN
Mol. Mass.:
27930.26
Organism:
Sheep
Description:
ChEMBL_107628
Residue:
256
Sequence:
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM80521
Synonyms:
3-Hydroxy-2-naphtho-p-phenetidide | 3-hydroxy-N-p-phenetyl-2-naphthamide | MLS000736677 | N-(4-ethoxyphenyl)-3-hydroxy-2-naphthalenecarboxamide | N-(4-ethoxyphenyl)-3-hydroxynaphthalene-2-carboxamide | N-(4-ethoxyphenyl)-3-oxidanyl-naphthalene-2-carboxamide | SMR000528245 | cid_78443
Type:
Small organic molecule
Emp. Form.:
C19H17NO3
Mol. Mass.:
307.3432
SMILES:
CCOc1ccc(NC(=O)c2cc3ccccc3cc2O)cc1
Structure:
Search PDB for entries with ligand similarity: