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Target
Major prion protein
Ligand
BDBM50437273
Substrate
n/a
Meas. Tech.
ChEMBL_972294 (CHEMBL2411805)
EC50
2200±n/a nM
Citation
 Li, Z; Rao, S; Gever, JR; Widjaja, K; Prusiner, SB; Silber, BM Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds. ACS Med Chem Lett 4:647-650 (2013) [PubMed]  Article 
Target
Name:
Major prion protein
Synonyms:
CD_antigen=CD230 | PRIO_SHEEP | PRNP | PRP | SIP
Type:
PROTEIN
Mol. Mass.:
27930.26
Organism:
Sheep
Description:
ChEMBL_107628
Residue:
256
Sequence:
MVKSHIGSWILVLFVAMWSDVGLCKKRPKPGGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGGWGQGGSHSQWNKPSKPKTNMKHVAGAAAAGAVVGGLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDRYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAYYQRGASVILFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM50437273
Synonyms:
CHEMBL1332508
Type:
Small organic molecule
Emp. Form.:
C25H27N3O2
Mol. Mass.:
401.5008
SMILES:
COc1cccc(c1)C(=O)Nc1ccc(cc1)N1CCN(Cc2ccccc2)CC1
Structure:
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