Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50334457
Substrate
n/a
Meas. Tech.
ChEMBL_985420 (CHEMBL2432449)
Ki
2148±n/a nM
Citation
 Banister, SD; Manoli, M; Barron, ML; Werry, EL; Kassiou, M N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes ass receptor ligands with potential neuroprotective effects. Bioorg Med Chem 21:6038-52 (2013) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50334457
Synonyms:
CHEMBL1643899 | N-(3-Fluorobenzyl)-8-aminopentacyclo[5.4.0.02,6.03,10.05,9]undecane
Type:
Small organic molecule
Emp. Form.:
C18H20FN
Mol. Mass.:
269.3565
SMILES:
Fc1cccc(CN[C@@H]2C3C4CC5C6CC(C3C46)C25)c1 |r,THB:9:16:14:12.18,8:18:16.17:14,10:17:14:12.18,11:12:16.17:14|
Structure:
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