Reaction Details Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM50440993
Substrate
n/a
Meas. Tech.
ChEMBL_985421 (CHEMBL2432450)
Ki
>10000±n/a nM
Citation
 Banister, SD; Manoli, M; Barron, ML; Werry, EL; Kassiou, M N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes ass receptor ligands with potential neuroprotective effects. Bioorg Med Chem 21:6038-52 (2013) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50440993
Synonyms:
CHEMBL2432045
Type:
Small organic molecule
Emp. Form.:
C18H21N
Mol. Mass.:
251.366
SMILES:
C(N[C@@H]1C2C3CC4C5CC(C2C35)C14)c1ccccc1 |r,THB:3:10:8:12.6,2:12:10.11:8,4:11:8:12.6,5:6:10.11:8|
Structure:
Search PDB for entries with ligand similarity: