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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50443364
Substrate
n/a
Meas. Tech.
ChEMBL_1275525 (CHEMBL3090540)
IC50
198±n/a nM
Citation
 Debenham, JS; Graham, TH; Verras, A; Zhang, Y; Clements, MJ; Kuethe, JT; Madsen-Duggan, C; Liu, W; Bhatt, UR; Chen, D; Chen, Q; Garcia-Calvo, M; Geissler, WM; He, H; Li, X; Lisnock, J; Shen, Z; Tong, X; Tung, EC; Wiltsie, J; Xu, S; Hale, JJ; Pinto, S; Shen, DM Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorg Med Chem Lett 23:6228-33 (2013) [PubMed]  Article 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM50443364
Synonyms:
CHEMBL3086044
Type:
Small organic molecule
Emp. Form.:
C36H37ClN2O
Mol. Mass.:
549.145
SMILES:
Cc1ccccc1C1CC(CCC1C(=O)N1CC(C1)(c1ccccc1)c1ccccc1)NCc1ccc(Cl)cc1
Structure:
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