Reaction Details Report a problem with these data
Target
Beta-secretase 2
Ligand
BDBM50428341
Substrate
n/a
Meas. Tech.
ChEMBL_1351639 (CHEMBL3269326)
IC50
5.0±n/a nM
Citation
Oehlrich, D; Prokopcova, H; Gijsen, HJ The evolution of amidine-based brain penetrant BACE1 inhibitors. Bioorg Med Chem Lett 24:2033-45 (2014) [PubMed] Article
More Info.:
Target
Name:
Beta-secretase 2
Synonyms:
BACE2_RAT | Bace2 | Beta-site APP cleaving enzyme 2 | Beta-site amyloid precursor protein cleaving enzyme 2 | Memapsin-1 | Membrane-associated aspartic protease 1 | Theta-secretase
Type:
PROTEIN
Mol. Mass.:
55848.42
Organism:
Rat
Description:
ChEMBL_1351639
Residue:
514
Sequence:
MGALLRALLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGLALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPCAEIAGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILLVLILLLLFPLHCRHAPRDPEVVNDESSLVRHRWK