Reaction Details Report a problem with these data
Target
P2Y purinoceptor 1
Ligand
BDBM50017089
Substrate
n/a
Meas. Tech.
ChEMBL_1365183 (CHEMBL3292933)
IC50
0.040000±n/a nM
Citation
 Jeon, YT; Yang, W; Qiao, JX; Li, L; Ruel, R; Thibeault, C; Hiebert, S; Wang, TC; Wang, Y; Liu, Y; Clark, CG; Wong, HS; Zhu, J; Wu, DR; Sun, D; Chen, BC; Mathur, A; Chacko, SA; Malley, M; Chen, XQ; Shen, H; Huang, CS; Schumacher, WA; Bostwick, JS; Stewart, AB; Price, LA; Hua, J; Li, D; Levesque, PC; Seiffert, DA; Rehfuss, R; Wexler, RR; Lam, PY Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent. Bioorg Med Chem Lett 24:1294-8 (2014) [PubMed]  Article 
Target
Name:
P2Y purinoceptor 1
Synonyms:
ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1
Type:
Enzyme
Mol. Mass.:
42090.25
Organism:
Homo sapiens (Human)
Description:
P47900
Residue:
373
Sequence:
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL
  
Inhibitor
Name:
BDBM50017089
Synonyms:
CHEMBL3287043 | US9428504, 8
Type:
Small organic molecule
Emp. Form.:
C32H34F3N5O3
Mol. Mass.:
593.6393
SMILES:
CC(C)(C)CN1CCC2(CN(c3c2c(ccc3O)C#N)c2ccccc2NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Structure:
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