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Target
Integrase
Ligand
BDBM50021589
Substrate
n/a
Meas. Tech.
ChEMBL_1364721 (CHEMBL3293763)
IC50
500±n/a nM
Citation
 Velthuisen, EJ; Johns, BA; Gerondelis, P; Chen, Y; Li, M; Mou, K; Zhang, W; Seal, JW; Hightower, KE; Miranda, SR; Brown, K; Leesnitzer, L Pyridopyrimidinone inhibitors of HIV-1 RNase H. Eur J Med Chem 83:609-16 (2014) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
Human immunodeficiency virus type 1 integrase
Type:
PROTEIN
Mol. Mass.:
32231.48
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_90865
Residue:
288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50021589
Synonyms:
CHEMBL3290944
Type:
Small organic molecule
Emp. Form.:
C17H17N5O3
Mol. Mass.:
339.3486
SMILES:
On1c2ncccc2c(Nc2ccc(cc2)N2CCOCC2)nc1=O
Structure:
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