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Target
Tyrosine-protein phosphatase non-receptor type 18
Ligand
BDBM50031906
Substrate
n/a
Meas. Tech.
ChEMBL_1437901 (CHEMBL3384865)
IC50
26400±n/a nM
Citation
 Hou, X; Li, R; Li, K; Yu, X; Sun, JP; Fang, H Fast identification of novel lymphoid tyrosine phosphatase inhibitors using target-ligand interaction-based virtual screening. J Med Chem 57:9309-22 (2014) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 18
Synonyms:
BDP1 | Brain-derived phosphatase | PTN18_HUMAN | PTPN18 | Tyrosine-protein phosphatase non-receptor type 18
Type:
PROTEIN
Mol. Mass.:
50490.92
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109521
Residue:
460
Sequence:
MSRSLDSARSFLERLEARGGREGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCSTLQNASPHYQNIKENCAPLYDDALFLRTPQALLAIPRPPGGVLRSISVPGSPGHAMADTYAVVQKRGAPAGAGSGTQTGTGTGTGARSAEEAPLYSKVTPRAQRPGAHAEDARGTLPGRVPADQSPAGSGAYEDVAGGAQTGGLGFNLRIGRPKGPRDPPAEWTRV
  
Inhibitor
Name:
BDBM50031906
Synonyms:
CHEMBL3360905
Type:
Small organic molecule
Emp. Form.:
C33H31N3O6S
Mol. Mass.:
597.681
SMILES:
CCOC(=O)C1=C(C)N=c2s\c(=C\c3ccc(OCc4ccc(cc4)C(O)=O)cc3)c(=O)n2C1c1ccc(cc1)N(C)C |c:5,t:8|
Structure:
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