Reaction Details Report a problem with these data
Target
Biotin--protein ligase
Ligand
BDBM50039494
Substrate
n/a
Meas. Tech.
ChEMBL_1445407 (CHEMBL3379106)
Ki
10400±n/a nM
Citation
Sittiwong, W; Cordonier, EL; Zempleni, J; Dussault, PH ฿-Keto and฿-hydroxyphosphonate analogs of biotin-5'-AMP are inhibitors of holocarboxylase synthetase. Bioorg Med Chem Lett 24:5568-71 (2014) [PubMed] Article
More Info.:
Target
Name:
Biotin--protein ligase
Synonyms:
BPL1_HUMAN | Biotin apo-protein ligase | Biotin--[acetyl-CoA-carboxylase] ligase | Biotin--[methylcrotonoyl-CoA-carboxylase] ligase | Biotin--[methylmalonyl-CoA-carboxytransferase] ligase | Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase | HCS | HLCS | Holocarboxylase synthetase
Type:
PROTEIN
Mol. Mass.:
80745.43
Organism:
Human
Description:
ChEMBL_1475435
Residue:
726
Sequence:
MEDRLHMDNGLVPQKIVSVHLQDSTLKEVKDQVSNKQAQILEPKPEPSLEIKPEQDGMEHVGRDDPKALGEEPKQRRGSASGSEPAGDSDRGGGPVEHYHLHLSSCHECLELENSTIESVKFASAENIPDLPYDYSSSLESVADETSPEREGRRVNLTGKAPNILLYVGSDSQEALGRFHEVRSVLADCVDIDSYILYHLLEDSALRDPWTDNCLLLVIATRESIPEDLYQKFMAYLSQGGKVLGLSSSFTFGGFQVTSKGALHKTVQNLVFSKADQSEVKLSVLSSGCRYQEGPVRLSPGRLQGHLENEDKDRMIVHVPFGTRGGEAVLCQVHLELPPSSNIVQTPEDFNLLKSSNFRRYEVLREILTTLGLSCDMKQVPALTPLYLLSAAEEIRDPLMQWLGKHVDSEGEIKSGQLSLRFVSSYVSEVEITPSCIPVVTNMEAFSSEHFNLEIYRQNLQTKQLGKVILFAEVTPTTMRLLDGLMFQTPQEMGLIVIAARQTEGKGRGGNVWLSPVGCALSTLLISIPLRSQLGQRIPFVQHLMSVAVVEAVRSIPEYQDINLRVKWPNDIYYSDLMKIGGVLVNSTLMGETFYILIGCGFNVTNSNPTICINDLITEYNKQHKAELKPLRADYLIARVVTVLEKLIKEFQDKGPNSVLPLYYRYWVHSGQQVHLGSAEGPKVSIVGLDDSGFLQVHQEGGEVVTVHPDGNSFDMLRNLILPKRR