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Target
Carbonic anhydrase 12
Ligand
BDBM50051026
Substrate
n/a
Meas. Tech.
ChEMBL_1460064 (CHEMBL3368598)
Ki
6.6±n/a nM
Citation
 Chegaev, K; Lazzarato, L; Tamboli, Y; Boschi, D; Blangetti, M; Scozzafava, A; Carta, F; Masini, E; Fruttero, R; Supuran, CT; Gasco, A Furazan and furoxan sulfonamides are stronga-carbonic anhydrase inhibitors and potential antiglaucoma agents. Bioorg Med Chem 22:3913-21 (2014) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50051026
Synonyms:
CHEMBL3309357
Type:
Small organic molecule
Emp. Form.:
C4H7N3O4S
Mol. Mass.:
193.181
SMILES:
CCOc1nonc1S(N)(=O)=O
Structure:
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