Reaction Details Report a problem with these data
Target
Beta-secretase 1
Ligand
BDBM50061582
Substrate
n/a
Meas. Tech.
ChEMBL_1461646 (CHEMBL3395115)
IC50
0.700000±n/a nM
Citation
Chen, JJ; Liu, Q; Yuan, C; Gore, V; Lopez, P; Ma, V; Amegadzie, A; Qian, W; Judd, TC; Minatti, AE; Brown, J; Cheng, Y; Xue, M; Zhong, W; Dineen, TA; Epstein, O; Human, J; Kreiman, C; Marx, I; Weiss, MM; Hitchcock, SA; Powers, TS; Chen, K; Wen, PH; Whittington, DA; Cheng, AC; Bartberger, MD; Hickman, D; Werner, JA; Vargas, HM; Everds, NE; Vonderfecht, SL; Dunn, RT; Wood, S; Fremeau, RT; White, RD; Patel, VF Development of 2-aminooxazoline 3-azaxanthenes as orally efficaciousß-secretase inhibitors for the potential treatment of Alzheimer's disease. Bioorg Med Chem Lett 25:767-74 (2015) [PubMed] Article
More Info.:
Target
Name:
Beta-secretase 1
Synonyms:
ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1)
Type:
Protein
Mol. Mass.:
55755.10
Organism:
Homo sapiens (Human)
Description:
P56817
Residue:
501
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK