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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50075951
Substrate
n/a
Meas. Tech.
ChEMBL_1473827 (CHEMBL3418726)
IC50
3500±n/a nM
Citation
 Huleatt, PB; Khoo, ML; Chua, YY; Tan, TW; Liew, RS; Balogh, B; Deme, R; Gölöncsér, F; Magyar, K; Sheela, DP; Ho, HK; Sperlágh, B; Mátyus, P; Chai, CL Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease. J Med Chem 58:1400-19 (2015) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50075951
Synonyms:
CHEMBL3415810
Type:
Small organic molecule
Emp. Form.:
C13H16ClN
Mol. Mass.:
221.726
SMILES:
Cl.CN(CC#C)CC(=C)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: