Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50079887
Substrate
n/a
Meas. Tech.
ChEMBL_1472723 (CHEMBL3418856)
Ki
227±n/a nM
Citation
 Varano, F; Catarzi, D; Squarcialupi, L; Betti, M; Vincenzi, F; Ravani, A; Varani, K; Dal Ben, D; Thomas, A; Volpini, R; Colotta, V Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation. Eur J Med Chem 96:105-21 (2015) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Homo sapiens (Human)
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50079887
Synonyms:
CHEMBL3415040
Type:
Small organic molecule
Emp. Form.:
C10H8N4OS
Mol. Mass.:
232.262
SMILES:
Cc1nc2sc(nc2c(=O)[nH]1)-n1cccc1
Structure:
Search PDB for entries with ligand similarity: