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Target
Glycylpeptide N-tetradecanoyltransferase 1
Ligand
BDBM50148269
Substrate
n/a
Meas. Tech.
ChEMBL_1556710 (CHEMBL3773953)
Ki
20±n/a nM
Citation
 Rackham, MD; Yu, Z; Brannigan, JA; Heal, WP; Paape, D; Barker, KV; Wilkinson, AJ; Smith, DF; Leatherbarrow, RJ; Tate, EW Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase. Medchemcomm 6:1761-1766 (2016) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase 1
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:
Enzyme
Mol. Mass.:
56814.10
Organism:
Human
Description:
P30419
Residue:
496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
  
Inhibitor
Name:
BDBM50148269
Synonyms:
CHEMBL3770219
Type:
Small organic molecule
Emp. Form.:
C20H24ClN5O2
Mol. Mass.:
401.89
SMILES:
Cc1nn(C)c(C)c1Cc1nnc(o1)-c1cc(Cl)ccc1OC1CCNCC1
Structure:
Search PDB for entries with ligand similarity: