Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 2
Ligand
BDBM50153477
Substrate
n/a
Meas. Tech.
ChEMBL_1560844 (CHEMBL3778916)
EC50
0.630000±n/a nM
Citation
Erchegyi, J; Wang, L; Gulyas, J; Samant, M; Perrin, MH; Lewis, K; Miller, C; Vaughan, J; Donaldson, C; Fischer, W; Low, W; Yakabi, S; Karasawa, H; Taché, Y; Rivier, C; Rivier, J Characterization of Multisubstituted Corticotropin Releasing Factor (CRF) Peptide Antagonists (Astressins). J Med Chem 59:854-66 (2016) [PubMed] Article
More Info.:
Target
Name:
Corticotropin-releasing factor receptor 2
Synonyms:
CRF-R-2 | CRF-R2 | CRF2 Beta | CRFR-2 | CRFR2_RAT | CRH-R-2 | CRH-R2 | Corticotropin releasing factor receptor | Corticotropin-releasing factor receptor 2 | Corticotropin-releasing hormone receptor 2 | Crf2r | Crhr2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47697.09
Organism:
Rat
Description:
CRF2 Beta 0 RAT::P47866
Residue:
411
Sequence:
MDAALLLSLLEANCSLALAEELLLDGWGEPPDPEGPYSYCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIINYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNITWFLLQLIDHEVHEGNEVWCRCVTTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIVAWAVGKLYYENEQCWFGKEPGDLVDYIYQGPIILVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRSALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
Inhibitor
Name:
BDBM50153477
Synonyms:
CHEMBL3775524
Type:
Small organic molecule
Emp. Form.:
C177H298N50O49
Mol. Mass.:
3910.5656
SMILES:
CCCCC(NC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CC(O)=O)NC(C)=O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(CCCNC(N)=N)C(=O)NC(C)C(=O)NC(CCC(O)=O)C(=O)NC(CCC(N)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC1CCC(=O)NCCCCC(NC(=O)C(C)(C)NC(=O)C(C)NC1=O)C(=O)NC(CC(N)=O)C(=O)NC(CCCNC(N)=N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCC)C(=O)NC(CCC(O)=O)C(=O)NC(C)(CC(C)C)C(=O)NC(C(C)CC)C(N)=O